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PGS GENETIC SELECTION
Genetically selected embryo transfer
Preimplantation genetic testing (PGT) is a crucial tool in the field of assisted reproductive technology, allowing couples to screen embryos for genetic disorders before implantation. This process is done during the IVF process, after the eggs have been retrieved and fertilized to form embryos.
PGT refers to the three types of tests that may be performed on embryos during IVF:
- PGT-A (formally PGS)
- PGT-SR (formally PGD)
- PGT-M (formally PGD)
PGT-A, or Preimplantation Genetic Testing for Aneuploidy, is a highly advanced procedure that involves screening all 23 pairs of human chromosomes in embryos obtained through IVF. This allows for the accurate detection of any extra or missing chromosomes, which can significantly impact the success of an IVF cycle or the likelihood of a healthy pregnancy. PGT-A is particularly recommended for women who are 35 years or older, as well as those who have experienced multiple miscarriages or failed IVF cycles. Additionally, PGT-A can also be used for gender selection, whether for medical reasons or for family balancing purposes.
At Dogus IVF clinic, we offer two techniques for performing PGT-A. The first technique is Next-generation sequencing (NGS), which involves testing all 23 pairs of chromosomes. This is done by performing an embryo biopsy on Day 5 of embryo development and sending a few cells from the placenta to the laboratory for testing.
PGT refers to the three types of tests that may be performed on embryos during IVF:
- PGT-A (formally PGS)
- PGT-SR (formally PGD)
- PGT-M (formally PGD)
PGT-A, or Preimplantation Genetic Testing for Aneuploidy, is a highly advanced procedure that involves screening all 23 pairs of human chromosomes in embryos obtained through IVF. This allows for the accurate detection of any extra or missing chromosomes, which can significantly impact the success of an IVF cycle or the likelihood of a healthy pregnancy. PGT-A is particularly recommended for women who are 35 years or older, as well as those who have experienced multiple miscarriages or failed IVF cycles. Additionally, PGT-A can also be used for gender selection, whether for medical reasons or for family balancing purposes.
At Dogus IVF clinic, we offer two techniques for performing PGT-A. The first technique is Next-generation sequencing (NGS), which involves testing all 23 pairs of chromosomes. This is done by performing an embryo biopsy on Day 5 of embryo development and sending a few cells from the placenta to the laboratory for testing.
The embryos are then frozen until the test results are available in 2- 3 weeks. Based on the test result, aneuploid and mosaic embryos are discarded, while euploid embryos are stored for future transfer.
The second technique we offer is Fluorescence in situ hybridization (FISH), which tests for the 13, 16, 18, 21, 22, X, and Y chromosomes. This technique involves performing an embryo biopsy on Day 3 of embryo development and sending the cells to the laboratory for testing. The results are available in just 1-2 days, allowing for fresh embryo transfer to be performed on Day 5 of embryo development. Both techniques allow us to accurately identify and select the healthiest embryos for transfer, increasing the chances of a successful pregnancy for our patients.
PGT-M or Preimplantation Genetic Testing for monogenic disorders, is a powerful tool for detecting abnormalities or changes in a single gene within embryos that may lead to a monogenic disorder. This test can identify various types of hereditary diseases, including autosomal recessive, autosomal dominant, and X-linked disorders such as cystic fibrosis, Huntington's disease, Fragile X syndrome, hemophilia A, sickle cell anemia, and the Marfan syndrome.This test is recommended for couples who have a history of genetic disorders, as well as those where one partner has been diagnosed with a genetic disorder. It is also useful for couples where both partners are carriers of the same genetic condition.
PGT-SR or Preimplantation Genetic Testing for Structural Rearrangements, is a procedure that identifies chromosomal abnormalities in embryos caused by the improper joining or breakage of chromosome segments. These can include various types such as translocations, deletions, duplications, insertions, rings, or inversions, which can be either balanced or unbalanced. Certain structural rearrangements can lead to genetic disorders, making it crucial for couples to undergo PGT-SR if one partner carries a chromosomal structural rearrangement. PGT-SR plays a vital role in identifying and preventing potential genetic disorders caused by structural rearrangements.